What is the prevalence of GERD in a population-based study?
G.R. Locke III (Rochester) Full article (members only)

Why is reflux esophagitis a predominantly male disease?
J. Sarosiek, R.W. McCallum (Kansas City) Full article (members only)

Why is the striking male predominance of GERD in adults not found in young children?
Y. Vandenplas (Brussels) Full article (members only)

Is the pathophysiology of regurgitant reflux in infants known?
S.R. Orenstein (Pittsburgh) Full article (members only)

Is there a correlation between scoring of GERD and the prevalence of symptoms?
R.M. Bremner, S.F. Hoeft, T.R. DeMeester (Los Angeles), M. Costantini (Padova) Full article (members only)

What factors may predict esophagitis in patients with GER?
J. Vatier, G. Cadiot, M. Mignon (Paris) Full article (members only)

Is the labeled food gastric emptying study reliable and of value in childhood GER?
C. Di Lorenzo (Pittsburgh) Full article (members only)

When is manometry indicated for reflux esophagitis? Do results of conventional manometry have therapeutic implications?
M. Gadenstätter (Innsbruck), C.G. Bremner (Los Angeles) Full article (members only)

Is the role of non acid GER in the pathogenesis of reflux esophagitis overestimated?
S. Mattioli, F. D'Ovidio, M. Pastina, M.P. Di Simone, L. Ferruzzi (Bologna) Full article (members only)

Can scanning electron microscopy be considered as a diagnostic test for GER disease?
B.T. Johnston, S. Nunn (Belfast) Full article (members only)

Can mucosal damage in GERD be graded endoscopically?
G.N.J. Tytgat (Amsterdam) Full article (members only)

Epithelial resistance

How can the lack of correlation between severity of clinical symptoms and mucosal injury be explained?
K. Geboes, N. Ectors (Leuven) Full article (members only)

Is there any correlation between alkaline reflux and the severity of esophagitis?
I. Braghetto, A. Csendes, P. Burdiles, O. Korn (Santiago) Full article (members only)

Is the gastric cardiac epithelium likely to be injured by reflux?
C.G. Bremner (Los Angeles) Full article (members only)

What is the relation between acid reflux, esophageal glycoconjugate (mucin) secretion, and viscosity?
J. Sarosiek, M. Marcinkiewicz, T. Zbroch, Z. Namiot (Kansas City) Full article (members only)

What is the correlation between the histological morphometric parameters and esophagitis in adults? In infants?
S.R. Orenstein (Pittsburgh) Full article (members only)

Is the effect of extracellular acidification on intracellular pH modified by pepsin?
N.A. Tobey (New Orleans) Full article (members only)

What are the mechanisms by which hydrogen ions damage the esophageal epithelium?
R.C. Orlando (New Orleans) Full article (members only)

What are the mechanisms involved in mucosal adaptative cytoprotection?
A.I. Lanas, J. Ortego (Zaragoza) Full article (members only)

What is known about the distribution and expression of growth factors, such as EGF and TGFa and their receptors, in the defense of the esophageal mucosa, and in healing of reflux induced injury?
A. Calabrò, B. Orsini, D. Renzi, L. Papi, S. Milani, C. Surrenti (Florence) Full article (members only)

What regulates bicarbonate secretion by esophageal submucosal glands?
N.A. Tobey (New Orleans) Full article (members only)

What is the role of salivary and esophageal PGE₂ in esophageal protection?
J. Sarosiek, M. Marcinkiewicz, T. Zbroch, R.W. McCallum (Kansas City) Full article (members only)

Is salivary PGE₂ output stimulated by esophageal inflammation?
J. Sarosiek, T. Zbroch, M. Marcinkiewicz, Z. Namiot (Kansas City) Full article (members only)

What is the relationship between free-radical release and extent of mucosal damage?
G.J. Wetscher, C. Profanter (Innsbruck), R.A. Hinder (Jacksonville) Full article (members only)

Respiratory disorders

Pharyngitis, laryngitis in the adult, and GER
C. Beauvillain de Montreuil (Nantes) Full article (members only)

Pseudo-asthma and GER
W.P. Mulloy (Philadelphia) Full article (members only)

What is the value of bronchial scintigraphy in conjunction with a meal?
D.S. Brandt, T.P. Chaudhuri, E.M. Smith (Hampton) Full article (members only)

       What are the potential mechanisms for esophageal acid-induced bronchoconstriction?
           S.J. Sontag (Hines) Full article (members only)

Of what value is the symptom association chance for this evaluation?
S.J. Sontag (Hines) Full article (members only)

Is the role of proximal acid reflux in respiratory symptoms prevalent in infants?
S.G. Jolley (Las Vegas), D.G. Johnson (Salt Lake City) Full article (members only)

What role does surgery have in treating these disorders?
M.G. Patti (San Francisco), A. Porter, C.A. Pellegrini (Seattle) Full article (members only)

What is the effect of documented acid suppression on asthma symptoms? On expiratory flow rates?
S.M. Harding (Birmingham) Full article (members only)

What are the predictors of response?
S.M. Harding (Birmingham) Full article (members only)

What is the effect of CPAP (continuous positive airway pressure) in limiting symptoms of nocturnal reflux?
J.P. Shoenut, P. Kerr, M.H. Kryger (Winnipeg) Full article (members only)

Is home CPAP a means of treatment for patients with nocturnal reflux resistant to treatment?
J.P. Shoenut, P. Kerr, M.H. Kryger (Winnipeg) Full article (members only)